Effexor did not work at 75 mg. so my doctor upped it to 150mg. Side effects were that the drug made me feel euphoric and tremendously increased my sex drive. However, just as quickly as my mood improved, it all of a sudden dropped off. My doctor then increased the dose to 225mg and again my sex drive went through the roof, but then I dropped off again and became depressed. My doctor weaned me off of it very gradually. It works well for my husband and does not bother him sexually at all.