Celexa was the first medication I tried, it took about two weeks for it to kick in. It made me a little sleepy and I felt a little sick one time, but not for very long. I have been fairly stable as far as my depression goes since I have been on it, although I was also on it for Anxiety and it worked quite well for that too. Before if I went our of the house alone, I freaked out, my heart raced and it was hard to breathe, but now, it's okay. The only other side affect I got from it, is if I forget to take me meds one day I get dizzy and I get a headache. and if I don't take them at the same time every day my jaw gets tremors like I'm shivering cause I'm cold, even though I'm not cold. My doc said that's a pretty usual reaction though.