Effexor worked rather well for me - very few side effects other than headaches and insomnia. No upset stomach, no weight changes or anxiety. However, I found that at higher dosages (anything above 75 mg) I felt "out of touch" with all emotions - I was flat, unable to feel, and began to feel like I was losing my ability to function. Eventually, these effects prompted me to discontinue my use of Effexor.